Transcriptomic Sequencing of Airway Epithelial Cell NCI-H292 Induced by Synthetic Cationic Polypeptides

Transcriptomic Sequencing of Airway Epithelial Cell NCI-H292 Induced by Synthetic Cationic Polypeptides

April 18, 2019 0 Comments

Copyright © 2019 Ya-Ni Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Eosinophil asthma is characterized by the infiltration of eosinophils to the bronchial epithelium. The toxic cationic protein released by eosinophils, mainly major basic protein (MBP), is one of the most important causative factors of epithelium dama...

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Cancer cells resist mechanical destruction in the circulation via RhoA-myosin II axis

April 09, 2019 0 Comments

During metastasis cancer cells are exposed to potentially destructive hemodynamic forces including fluid shear stress (FSS) while en route to distant sites. However, prior work indicates that cancer cells are more resistant to brief pulses of high-level fluid shear stress (FSS) in vitro relative to non-transformed epithelial cells. Herein we identify a mechanism of FSS resistance in cancer cells, and extend these findings to mouse models of circulating tumor cells (CTCs). We show that cancer cel...

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The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

April 09, 2019 0 Comments

IJMS | Free Full-Text | The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma Next Article in Journal New Innovations in Wound Healing and Repair Previous Article in Journal Crude α-Mangostin Suppresses the Development of Atherosclerotic Lesions in Apoe-Deficient Mice by a Possible M2 Macrophage-Mediated Mechanism Previous Article in Special Is...

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Detection and Identification of O-GlcNAc-modified Proteins by 6-Azido-6-deoxy-N-acetyl-galactosamine | Slick Finder

April 09, 2019 0 Comments

user warning: Table './slickfinder_drupal/cache_block' is marked as crashed and should be repaired query: SELECT data, created, headers, expire, serialized FROM cache_block WHERE cid = 'ad:0:aurora:http://slickfinder.com/content/detection-and-identification-o-glcnac-modified-proteins-6-azido-6-deoxy-n-acetyl-galactosami' in /var/www/vhosts/slickfinder.com/httpdocs/includes/cache.inc on line 25. user warning: Table './slickfinder_drupal/cache_block' is marked as crashed and should be repaired que...

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Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells

Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells

April 09, 2019 0 Comments

Copyright © 2019 Ghazaleh M. Shahriary et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Microglia play diverse roles in homeostasis and pathology of the central nervous system (CNS). Their response to injury or insult is critical for initiating neuroinflammation and tissue damage as well as resolution of inflammation and woun...

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NCBS FREE Training Program in REPROGRAMMING HUMAN SOMATIC CELLS TO INDUCED PLURIPOTENT STEM CELLS | June 3-14, 2019

NCBS FREE Training Program in REPROGRAMMING HUMAN SOMATIC CELLS TO INDUCED PLURIPOTENT STEM CELLS | June 3-14, 2019

April 09, 2019 0 Comments

This workshop aims to expand the expertise for stem cell research in India and focuses on techniques involved in generation and maintenance of high quality HiPSCs from human somatic cells. Participants will be trained on all aspects of reprogramming, culture and characterization of stem cell lines. The course combines hands on training sessions and lectures from experts in the field.  Selection procedure: An expert committee will screen the applications and the selection is based on qualificat...

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Hope Medicine announced global license agreement with Bayer AG to advance the development and commercialization of the monoclonal antibody directed against prolactin (PRL) receptor | Markets Insider

Hope Medicine announced global license agreement with Bayer AG to advance the development and commercialization of the monoclonal antibody directed against prolactin (PRL) receptor | Markets Insider

April 09, 2019 0 Comments

BEIJING, April 7, 2019 /PRNewswire/ -- Hope Medicine Inc. announced today that they have signed a world-wide exclusive license agreement with Bayer AG on the development and commercialization of a human antibody targeting the PRL receptor for the treatment of male and female pattern hair loss, endometriosis and other chronic diseases with dysregulated PRL signaling. The inauguration of Hope Medicine Inc. ("HopeMed"), a new biopharmaceutical company focused on advancing novel therapies to improve...

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CiteULike: Effects of 8 Weeks Aerobic Training on Plasma Ghrelin Level and Ghrelin Lymphocyte Gene Expression in Elderly Men

April 09, 2019 0 Comments

CiteULike: Effects of 8 Weeks Aerobic Training on Plasma Ghrelin Level and Ghrelin Lymphocyte Gene Expression in Elderly Men x CiteULike uses cookies, some of which may already have been set. Read about how we use cookies. We will interpret your continued use of this site as your acceptance of our use of cookies. You may hide this message. Effects of 8 Weeks Aerobic Training on Plasma Ghrelin Level and Ghrelin Lymphocyte Gene Expression in Elderly Men This copy of the article hasn't b...

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Hybridizing Anions towards Fast Diffusion Kinetics for Tri-Ion Batteries with Significantly Improved Rate Capability and Cycling Life - Journal of Materials Chemistry A (RSC Publishing)

April 09, 2019 0 Comments

Dual-ion batteries are promising candidates for next-generation energy storage devices for their merits of low cost, environmental friendliness and easy recovery. However, intercalation/deintercalation of large anions usually causes slow ion diffusion kinetics and large volume variation in graphite cathode leading to unsatisfactory rate capability and poor cycling stability. Herein, we report a new aluminum-graphite tri-ion (Li+/PF6-/BF4-) battery configuration (named as AGTIB) using an anion-hy...

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Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets

Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets

April 06, 2019 0 Comments

Systemic sclerosis (SSc or scleroderma) is a rare multisystem, connective tissue disease characterized by cutaneous and visceral fibrosis, immune dysregulation, and vasculopathy. Patients are commonly classified into two main clinical subsets on the basis of the extent of skin thickening: limited or restricted cutaneous SSc (lcSSc) and diffuse or widespread cutaneous SSc (dcSSc). The etiology of SSc remains elusive. The low concordance rate in monozygotic twins and relatively modest genetic burd...

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Flow Cytometry Market Size Poised to Uplift Around USD 8.0 Billion By 2025: Grand View Research, Inc. | Kota News Desk

April 06, 2019 0 Comments

According to report published by Grand View Research, the increasing incidence of infectious diseases and cancer is expected to upsurge the demand for flow cytometers for use in disease diagnosis over the coming years. In addition, higher number of physicians is inclined toward the usage of autologous and allogenic stem cell therapy, due to adverse effects caused by chemotherapy & radiation therapy in the treatment of cancer, thereby affecting the growth of this market. According to a report,“Fl...

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SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts

SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts

April 06, 2019 0 Comments

IJMS | Free Full-Text | SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts Next Article in Journal Low Serum Melatonin Levels Prior to Liver Transplantation in Patients with Hepatocellular Carcinoma are Associated with Lower Survival after Liver Transplantation Previous Article in Journal Regulation of Proliferation, Differentiation and F...

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Calcium Phosphate Dibasic Market 2019 Industry Size, Share, Future Growth Plans, Revenue, Comprehensive Study and 2024 Forecast Research « MarketersMEDIA – Press Release Distribution Services – News Release Distribution Services

April 06, 2019 0 Comments

April 4, 2019 /MarketersMedia/ — Global Calcium Phosphate Dibasic Market 2019 Industry report covers the latest market statistics, industry growth driving factors, size, share, trends, as well as Forecast till 2023. The Global Calcium Phosphate Dibasic market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.This report covered following regions-North America, China, Europe, Southeast Asia, Japan ...

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Two-Photon Probes for Golgi Apparatus: Detection of Golgi Apparatus in Live Tissue by Two-Photon Microscopy

Two-Photon Probes for Golgi Apparatus: Detection of Golgi Apparatus in Live Tissue by Two-Photon Microscopy

April 06, 2019 0 Comments

Two-Photon Probes for Golgi Apparatus: Detection of Golgi Apparatus in Live Tissue by Two-Photon Microscopy - Analytical Chemistry (ACS Publications) ...

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India's largest Rock Phosphate importers in February were Indian Farmers Fertiliser, Paradeep Phosphates, Coromandel Inter., Hindalco Industries & more. | Fertilizer Report

India's largest Rock Phosphate importers in February were Indian Farmers Fertiliser, Paradeep Phosphates, Coromandel Inter., Hindalco Industries & more. | Fertilizer Report

April 06, 2019 0 Comments

India's largest Rock Phosphate importers in February were Indian Farmers Fertiliser, Paradeep Phosphates, Coromandel Inter., Hindalco Industries & more. | Fertilizer Report Fertilizer Report is a global market intelligence platform that provides news, prices, directories, offers, reports and other value added information to the global fertilizer industry. India's largest Rock Phosphate importers in February were Indian Farmers Fertiliser, Paradeep Phosphates, Coromandel Inter., Hindalco Indus...

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Cell Culture Media Market 2018, Global Trends, Size, Key Players, Share, Future Perspective, Emerging Technologies, Competitive landscape and Analysis by Forecast to 2023

April 06, 2019 0 Comments

Cell culture media or media sera is one of the products that are used in the cell culture environment.  The market of media is had been growing pervasively over the last few years, thanks to the augmenting demand for biotechnological and biopharmaceuticals products from the pharmaceutical labs for the development of new drugs. Besides, the increasing prevalence of chronic diseases is prompting the need for effective medicines and treatment methods. Furthermore, the increasing use of cell culture...

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Public Policy, Chromosomes, Genes, and Societal “Cures”

Public Policy, Chromosomes, Genes, and Societal “Cures”

April 06, 2019 0 Comments

Thanks to everyone who read my previous blog post, “Iceland 'Cures' Down Syndrome, Should America Do the Same?” and a deepest expression of gratitude to all who took the time to comment. A recent response to this article was particularly striking: "Comparing people with Down's—a chromosomal abnormality—to women, who do not have any chromosomal abnormality, and implying the reason for wanting to terminate either type of pregnancy is the same is asinine…” I whole-heartedly concur with this reader’...

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Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells

Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells

April 06, 2019 0 Comments

Antioxidants | Free Full-Text | Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells Previous Article in Journal Juglone in Oxidative Stress and Cell Signaling Previous Article in Special Issue Antioxidant and Antimicrobial Activity of Rosemary, Pomegranate and Olive Extracts i...

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Global Phosphate Fertilizers Industry Market Research 2019 - MarketPressRelease

April 06, 2019 0 Comments

Bharat Book Bureau Provides the Trending Market Research Report on "Global Phosphate Fertilizers Industry Market Research 2019” under Chemical & Materials Category. The report offers a collection of superior market research, market analysis, and competitive intelligence and industry reports. In this report, we analyze the Phosphate Fertilizers industry from two aspects. One part is about its production and the other part is about its consumption. In terms of its production, we ana...

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Agenus Begins Dosing with Next-Gen Anti-CTLA-4 Antibody

Agenus Begins Dosing with Next-Gen Anti-CTLA-4 Antibody

April 04, 2019 0 Comments

LEXINGTON, Mass., April 2, 2019 /PRNewswire/ -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with a pipeline of immune-modulating antibodies, cancer vaccines, adjuvants and adoptive cell therapies1, today announced that the first patient was dosed in the clinical trial of its next-generation anti-CTLA-4 antibody (AGEN1181). AGEN1181, a novel 'Fc engineered' antibody with potential for enhanced anti-tumor functions, is specifically designed to boost cancer killing immune cells and deple...

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Failure of JIA Biologic Agents May Be Linked to ADAbs, Study Shows

Failure of JIA Biologic Agents May Be Linked to ADAbs, Study Shows

April 04, 2019 0 Comments

Approximately 17% of juvenile idiopathic arthritis (JIA) patients treated with biologic agents develop anti-drug antibodies (ADAbs) that can be associated with treatment failure and adverse events, a review study shows. Applying strategies to predict, prevent, detect, and manage ADAbs production may help improve care and outcomes in this young population, researchers suggest. The study, “Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis,” w...

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Synergistic effects of hydrogen-bonds and hybridized excited-state observed for high efficiency, deep-blue fluorescent emitter with narrow emission in OLED applications - Journal of Materials Chemistry C (RSC Publishing)

April 04, 2019 0 Comments

Synergistic effects of hydrogen-bonds and hybridized excited-state observed for high efficiency, deep-blue fluorescent emitter with narrow emission in OLED applications - Journal of Materials Chemistry C (RSC Publishing) Efficient deep-blue fluorescent and high color purity (narrow emission) are highly desired characteristics for the organic light-emitting diodes (OLEDs). Herein, we report the hydrogen-bonds (H-bonds) induced narrow emission based on a donor-acceptor type mol...

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Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions

April 04, 2019 0 Comments

Technologies that convert transient protein-protein interactions (PPIs) into stable expression of a reporter gene are useful for genetic selections, high-throughput screening, and multiplexing with omics technologies. We previously reported SPARK (Kim et al., 2017), a transcription factor that is activated by the coincidence of blue light and a PPI. Here, we report an improved, second-generation SPARK2 that incorporates a luciferase moiety to control the light-sensitive LOV domain. SPARK2 can be...

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SJRI Molecular/Cell Biology SRF Opening 2019 April

SJRI Molecular/Cell Biology SRF Opening 2019 April

April 04, 2019 0 Comments

SJRI Molecular/Cell Biology SRF Opening 2019 April ~ helpBIOTECH Home CSIR GATE Downloads About Us | CONTACT | Advertise ur Programs Post Jobs/Positions for FREE > Crossed 1.1 Crore Visitors helpBIOTECH TSSET 2019 PMRF 2019CEEB 2019 Subscribe: Enter your email: Delivered by FeedBurner Feature...

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Meiosis Worksheets Meiosis Chromosome

Meiosis Worksheets Meiosis Chromosome

April 04, 2019 0 Comments

meiosis worksheet - Learning regarding the actual value of money is among the primary training kids of today can learn. Most substantially you have to love them and you have to have `the present of teaching'. They are capable to draw a model associated with what they are reading to assist them understand the particular problem. You'll want to recognize, nevertheless, that not all goals are made equal. INTELLIGENT goals could be more helpful than the normal goal, but setting a INTELLIGENT aim rem...

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Know the latest trends in Castor Oil Market by top key players like NK Proteins, Jayant Agro Organics, Ambuja, Adani Group, Kanak, Adya Oil, RPK Agrotech, Gokul Overseas, Taj Agro Products, Girnar Industries, Bom Brazil - openPR

April 04, 2019 0 Comments

Up Market Research added a new Castor Oil Market research report for the period of 2019 – 2025. Report focuses on the major drivers and restraints providing analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Get Sample Copy Of This Report @ The report contains 107 pages which highly exhibit on current market analysis scenario, upcoming as well as future opportunities, revenue growth, pricing and profitability. Castor Oil Market research report de...

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Resolution Bio Liquid Biopsy Outperforms Guardant Test in Lung Cancer Gene Fusion Detection

Resolution Bio Liquid Biopsy Outperforms Guardant Test in Lung Cancer Gene Fusion Detection

April 04, 2019 0 Comments

NEW YORK (GenomeWeb) – Researchers from the Dana-Farber Cancer Institute and Resolution Biosciences have identified more actionable gene fusion mutations with higher allele frequencies in lung cancer patients using Resolution Bioscience's ctDx-Lung liquid biopsy test than using Guardant Health's Guardant360 assay. GenomeWeb Premium gives you: Never miss another important industry story. You may already have institutional access! Already a GenomeWeb or 360Dx Premi...

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Trials with monoclonal antibodies discussed at AD/PD 2019

Trials with monoclonal antibodies discussed at AD/PD 2019

April 04, 2019 0 Comments

At the 2019 International Congress on Alzheimer’s Disease (AD) and Parkinson’s disease (PD) in Lisbon, Portugal, scientists and researchesr presented the new opportunities and the lessons learnt in trials with monoclonal antibodies (mAbs). This followed all the failures that affected the AD pipeline, especially in AD drugs targeting the amyloid pathways, such as Roche’s crenezumab and lastly Biogen/Eisai aducanumab, the most promising drug in the AD pipeline. Several clinical trials of mAbs we...

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Retraction: Sensitizing Estrogen Receptor–negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor

Retraction: Sensitizing Estrogen Receptor–negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor

April 03, 2019 0 Comments

This article (1) has been retracted at the request of the editors. Following institutional review by the Ohio State University it was determined that Fig. 4A and B were intentionally falsified by Dr. Ching-Shih Chen. The authors regret any inconveniences or challenges resulting from the publication and subsequent retraction of this article. A copy of this Retraction Notice was sent to the last known email addresses for the authors. Three authors (S.K. Kulp, R.W. Brueggemeier, and C.L. Shapiro) a...

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Gene Transfer Improves Diabetes-linked Heart Ailment

Gene Transfer Improves Diabetes-linked Heart Ailment

April 03, 2019 0 Comments

Researchers with the VA San Diego Healthcare System and the University of California San Diego have shown that a gene transfer technique can combat heart dysfunction caused by diabetes. Working with mice, the researchers showed that a single injection to promote the expression of the hormone urocortin 2 (UCn2) increased left ventricle function and improved how the body processed glucose. The study could lead to new clinical treatments for diabetes-related left ventricle dysfunction, they say. ...

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No chromosome left behind: The importance of metaphase alignment for mitotic fidelity

No chromosome left behind: The importance of metaphase alignment for mitotic fidelity

April 03, 2019 0 Comments

During mitosis, chromosomes align at the spindle equator to establish a metaphase plate. This process, termed chromosome congression, was speculated to promote mitotic fidelity by “forcing” the chromosomes to enter anaphase from the same starting line, followed by their synchronous poleward movement, thereby preventing chromosome dispersion (1; Fig. 1 A). However, appreciating the physiological relevance of chromosome congression for mitotic fidelity has proven difficult because it is technicall...

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Study Finds Flavoring Chemicals in E-Cigarettes Induce Genetic Changes, Impair Functionality of Bronchial Epithelial Cells | Kraft Elder Law

April 03, 2019 0 Comments

Reuters reported a small test tube experiment examining the effect of e-cigarette flavoring chemicals on bronchial epithelial cells “found that both chemicals induced hundreds of genetic changes in the cells,” and “impaired the ability of the cells to function properly.” The chemicals studied were diacetyl “and its ‘chemical cousin’ 2,3-pentanedione.” Study co-author Joseph Allen, from the Harvard T.H. Chan School of Public Health explained that while “these flavoring chemicals are what we call ...

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Kura Oncology : Identifies Farnesylated Proteins Associated with CXCL12 Expression, Potential Biomarker of Clinical Benefit from Tipifarnib in Lymphoma Indications | MarketScreener

Kura Oncology : Identifies Farnesylated Proteins Associated with CXCL12 Expression, Potential Biomarker of Clinical Benefit from Tipifarnib in Lymphoma Indications | MarketScreener

April 03, 2019 0 Comments

SAN DIEGO, April02, 2019(GLOBE NEWSWIRE) -- Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company focused on the development of precision medicines for oncology, reported new findings regarding the mechanism of action of the Company’s lead drug candidate tipifarnib and its potential clinical applications. These findings are being presented today at the American Association for Cancer Research (AACR) Annual Meeting 2019 in Atlanta. A copy of the poster is available on...

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A Red Mitochondria-Targeted AIEgen for Visualizing H2S in Living Cells and Tumours - Analyst (RSC Publishing)

April 03, 2019 0 Comments

Hydrogen sulfide (H2S) exits in the cytosols and mitochondria of mammalian cells as a signaling molecule. The scientists have explored many important physiological functions of H2S, such as regulating vasodilator relaxation, protecting living cells avoiding damage. The measurement for H2S is necessary to explore in biological function of cells and tissues. Herein, we design and synthesize a new aggregation-induced emission luminogen (AIEgen) with more extent conjugate and more positive charge ba...

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Phosphate Rocks Market 2019 Witness Highest Growth In Near Future Leading Key Players PhosAgro, Solvay, The Mosaic, OCP, JPMC - openPR

April 03, 2019 0 Comments

Up Market Research added a new Phosphate Rocks Market research report for the period of 2019 – 2026. Report focuses on the major drivers and restraints providing analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Get Sample Copy Of This Report @ www.upmarketresearch.com/home/requested_sample/75743 The report contains 96 pages which highly exhibit on current market analysis scenario, upcoming as well as future opportunities, revenue growth, pric...

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Science: Evidence for link between ‘leaky gut’ and autoantibody production in HIV-positive patients

Science: Evidence for link between ‘leaky gut’ and autoantibody production in HIV-positive patients

April 03, 2019 0 Comments

Reportes de Audio viernes, diciembre 28th, 2018 02:24 pm GMT -3 Libertades condicionales: Bancada PC/PRO valora el avance contra de la impunidad de violadores a los... miércoles, julio 11th, 2018 05:06 pm GMT -3 Política: Jefa de Bancada Regionalista valoró rechazo de censura y acusó orquestación desde La Moned... ...

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ImmunoPrecise Launches DeepDisplay(™) Antibody Discovery Platform - ImmunoPrecise Launches Large-Scale Discovery Program with US Pharma Company - ImmunoPrecise Antibodies LTD

ImmunoPrecise Launches DeepDisplay(™) Antibody Discovery Platform - ImmunoPrecise Launches Large-Scale Discovery Program with US Pharma Company - ImmunoPrecise Antibodies LTD

April 03, 2019 0 Comments

VICTORIA, April 2,2019 / – IMMUNOPRECISE ANTIBODIES LTD. (the “Company” or “IPA”) (TSX VENTURE: IPA) (OTC PINK: IPATF) announces the expansion of their service offerings in therapeutic antibody discovery to select rare, fully human antibodies using DeepDisplay™, a combination of transgenic animal immunization and custom phage display antibody selection. ImmunoPrecise has launched, in response to a large-scale discovery program with an unnamed, US-based Pharma company, a powerful and unique platf...

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Live Cell Imaging Market Share, Size, Trends, Growth, Global Demand, Regional Overview and Forecast by 2023 | Finds MRFR

April 03, 2019 0 Comments

Global Live Cell Imaging Industry ReportForecast to 2023 is latest research report published by “Market Research Future”, which provides comprehensive information on Live Cell Imaging Market – Trends, Size, Share, Statistics with historic and forecast data to 2023. The live cell imaging market is eyeing for an impressive growth at a stupendous 9% CAGR during the forecast period (2018-2023). Live cell imaging simply put, is the utilization of time lapse microscopy for studying the living cells...

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Agenus Begins Dosing with Next-Gen Anti-CTLA4 Antibody | BioSpace

April 03, 2019 0 Comments

LEXINGTON, Mass., April 2, 2019 /PRNewswire/ -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with a pipeline of immune-modulating antibodies, cancer vaccines, adjuvants and adoptive cell therapies1, today announced that the first patient was dosed in the clinical trial of its next-generation anti-CTLA4 antibody (AGEN1181). AGEN1181, a novel ‘Fc engineered’ antibody with potential for enhanced anti-tumor functions, is specifically designed to boost cancer killing immune cells and deplet...

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Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

April 03, 2019 0 Comments

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies (humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a synthetic glyco-adjuvant named p(Man–TLR7), which, when conjugated to antigens, elicits robust humoral and cellular immunity. p(Man–TLR7) is a random copolymer composed of monomers that either target dendritic cells (DCs) via mannose-binding receptors or activate DCs via Toll-like receptor 7 (TLR7). Protein antigens ar...

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Cinnamaldehyde in Flavored E-Cigarette Liquids Temporarily Suppresses Bronchial Epithelial Cell Ciliary Motility by Dysregulation of Mitochondrial Function.

Cinnamaldehyde in Flavored E-Cigarette Liquids Temporarily Suppresses Bronchial Epithelial Cell Ciliary Motility by Dysregulation of Mitochondrial Function.

April 03, 2019 0 Comments

Aldehydes in cigarette smoke (CS) impair mitochondrial function and reduce ciliary beat frequency (CBF), leading to diminished mucociliary clearance (MCC). However, the effects of aldehyde e-cigarette flavorings on CBF is unknown. The purpose of this study was to investigate whether cinnamaldehyde, a flavoring agent commonly used in e-cigarettes, disrupts mitochondrial function and impairs CBF on well-differentiated human bronchial epithelial (hBE) cells. To this end, hBE cells were exposed to d...

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Computational characterization of the peptidome in transporter associated with antigen processing (TAP)-deficient cells

Computational characterization of the peptidome in transporter associated with antigen processing (TAP)-deficient cells

April 03, 2019 0 Comments

The transporter associated with antigen processing (TAP) is a key element of the major histocompatibility complex (MHC) class I antigen processing and presentation pathway. Nonfunctional TAP complexes impair the translocation of cytosol-derived proteolytic peptides to the endoplasmic reticulum lumen. This drastic reduction in the available peptide repertoire leads to a significant decrease in MHC class I cell surface expression. Using mass spectrometry, different studies have analyzed the cellul...

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Global Natural Protein Powder Market Analysis & Forecast Report, 2019-2023 - The Increase in the Number of Product Launches is a Major Driver - ResearchAndMarkets.com

Global Natural Protein Powder Market Analysis & Forecast Report, 2019-2023 - The Increase in the Number of Product Launches is a Major Driver - ResearchAndMarkets.com

April 03, 2019 0 Comments

The “Global Natural Protein Powder Market 2019-2023” report has been added to ResearchAndMarkets.com’s offering. The natural protein powder market will register a CAGR of over 8% by Consciousness of health and fitness is one of the primary factors driving the market As people are becoming more heath conscious, their concentration and the emphasis on maintaining a healthy and balanced diet, physical exercise, and active lifestyle have grown. This has intensified...

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Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.

Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.

April 03, 2019 0 Comments

Exposure of mammalian fetuses to endocrine disruptors can increase the risk of adult-onset diseases. We previously showed that exposure of mouse fetuses to bisphenol A (BPA) caused adult-onset obesity. To examine roles of epigenetic changes in this delayed toxicity, we determined the effects of fetal mouse exposure to BPA on genome-wide DNA methylation and messenger RNA (mRNA) expression in gonadal white adipose tissues (WATs) by deep sequencing, bisulfite pyrosequencing, and real-time quantitat...

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Distinct Effects of Royal Jelly on Human Endothelial Cells Under High Glucose Condition.

Distinct Effects of Royal Jelly on Human Endothelial Cells Under High Glucose Condition.

April 03, 2019 0 Comments

To assess different effects of royal Jelly in protecting the human endothelial cells from high glucose level, human umbilical vein endothelial cells were exposed to various concentrations of royal jelly, from 0.625 to 10 mg/mL, at the presence of 5 and 30 mM glucose contents over a course of 72 h. In addition to cell viability assessment by conventional MTT assay, we also analyzed the feature of stemness by expression of Sox-2 and CD133 factors. Moreover, fatty acid profile, the expression of au...

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Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation.

Thymol improves barrier function and attenuates inflammatory responses in porcine intestinal epithelial cells during lipopolysaccharide (LPS)-induced inflammation.

April 03, 2019 0 Comments

It is well known that essential oil thymol exhibits antibacterial activity. The protective effects of thymol on pig intestine during inflammation is yet to be investigated. In this study, an in vitro lipopolysaccharide (LPS)-induced inflammation model using IPEC-J2 cells was established. Cells were pre-treated with thymol for 1 h and then exposed to LPS for various assays. Interleukin 8 (IL-8) secretion, the mRNA abundance of cytokines, reactive oxygen species (ROS), nutrient transporters, and t...

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Mitochondria: Vol. 2 Comic 1 | Daily Trojan

Mitochondria: Vol. 2 Comic 1 | Daily Trojan

April 03, 2019 0 Comments

Mitochondria: Vol. 2 Comic 1 | Daily Trojan Mitochondria: Vol. 2 Comic 1 | Daily Trojan Facebook Twitter Youtube Instagram Rss Mail News Campus City Crime Housing Speakers and Events Lifestyle Columns Film Food Literature Music Theatre Sports Baseball Basketball Football Golf Women’s Lacrosse Rowing Sa...

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Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.

Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3.

April 03, 2019 0 Comments

Ginsenoside Rg3 is a key metabolite of ginseng and is known to inhibit cancer cell growth. However, the epigenetics of CpG methylation and its regulatory mechanism have yet to be determined. Genome-wide methylation analysis of MCF-7 breast cancer cells treated with Rg3 was performed to identify epigenetically regulated genes and pathways. The effect of Rg3 on apoptosis and cell proliferation was examined by a colony formation assay and a dye-based cell proliferation assay. The association betwee...

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20(s)-ginsenoside Rg3-loaded magnetic human serum albumin nanospheres applied to HeLa cervical cancer cells in vitro.

20(s)-ginsenoside Rg3-loaded magnetic human serum albumin nanospheres applied to HeLa cervical cancer cells in vitro.

April 03, 2019 0 Comments

20(s)-ginsenoside Rg3 is extracted from traditional Chinese medicine, red ginseng. However, due to its poor aqueous solubility and low oral bioavailability, the use of 20(s)-Rg3 is limited. This study aimed to explore a method of preparing nano-sized 20(s)-ginsenoside Rg3 particle named 20(s)-ginsenoside Rg3-loaded magnetic human serum albumin nanospheres (20(s)-Rg3/HSAMNP) to change dosage form to improve its aqueous solubility and bioavailability. 20(s)-Rg3/HSAMNP were prepared by the desolvat...

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Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses

Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses

April 03, 2019 0 Comments

http://orcid.org/0000-0002-5322-1435 http://orcid.org/0000-0002-2844-9673 http://orcid.org/0000-0001-7587-152X Lin Xu,  Jianmin Wu,  Qi Li,  Yamei Wei,  Zhizhou Tan,  Jianqiu Cai,  Huancheng Guo,  Ling’en Yang,  Xiaohong Huang,  Jing Chen Bats are newly identified reservoirs of hantaviruses (HVs) among which very divergent HVs have been ...

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