Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells

Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells

April 06, 2019 0 Comments

Antioxidants | Free Full-Text | Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells Previous Article in Journal Juglone in Oxidative Stress and Cell Signaling Previous Article in Special Issue Antioxidant and Antimicrobial Activity of Rosemary, Pomegranate and Olive Extracts in Fish Patties Choose your preferred view mode Please select whether you prefer to view the MDPI pages with a view tailored for mobile displays or to view the MDPI pages in the normal scrollable desktop version. This selection will be stored into your cookies and used automatically in next visits. You can also change the view style at any point from the main header when using the pages with your mobile device. 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Tzanetou Alexandros Priftis Sofia D. Koulocheri Serkos A. Haroutounian Demetrios Kouretas Dimitrios Stagos Advanced optionsEmail: Freq: One email with all search results One email for each search Renew × MOL Viewer × Open Access Article Antioxidants 2019, 8(4), 92; https://doi.org/10.3390/antiox8040092 (registering DOI) Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells Efthalia Kerasioti1,Anna Apostolou2,Ioannis Kafantaris1,Konstantinos Chronis1,Eleana Kokka1,Christina Dimitriadou1,Evangelia N. Tzanetou2,3,Alexandros Priftis1,Sofia D. Koulocheri2,Serkos A. Haroutounian2,Demetrios Kouretas1 andDimitrios Stagos1,* 1 Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, 41500 Larissa, Greece 2 Laboratory of Nutritional Physiology and Feeding, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece 3 Department of Pesticides Control and Phytopharmacy, Benaki Phytopathological Institute, 8 St. Delta Street, Kifissia, 14561 Athens, Greece * Author to whom correspondence should be addressed. Received: 6 March 2019 / Revised: 30 March 2019 / Accepted: 1 April 2019 / Published: 6 April 2019 (This article belongs to the Special Issue Antioxidant Activity of Polyphenolic Plant Extracts) PDF[1018 KB, uploaded 6 April 2019] Abstract The aim of the present study was the investigation of the antioxidant activity of plant extracts from Rosa canina, Rosa sempervivens and Pyrocantha coccinea. The results showed that the bioactive compounds found at higher concentrations were in the R. canina extract: hyperoside, astragalin, rutin, (+)-catechin and (-)-epicatechin; in the R. sempervirens extract: quinic acid, (+)-catechin, (−)-epicatechin, astragalin and hyperoside; and in the P. coccinea extract: hyperoside, rutin, (−)-epicatechin, (+)-catechin, astragalin, vanillin, syringic acid and chlorogenic acid. The total polyphenolic content was 290.00, 267.67 and 226.93 mg Gallic Acid Equivalent (GAE)/g dw, and the total flavonoid content 118.56, 65.78 and 99.16 mg Catechin Equivalent (CE)/g dw for R. caninna, R. sempervirens and P. coccinea extracts, respectively. The extracts exhibited radical scavenging activity in DPPH and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS)•+ assays and protection from ROO•-induced DNA damage in the following potency order: R. canina > R. sempervirens > P. coccinea. Finally, treatment with R. canina and P. coccinea extract significantly increased the levels of the antioxidant molecule glutathione, while R. canina extract significantly decreased Reactive Oxygen Species (ROS) in endothelial cells. The results herein indicated that the R. canina extract in particular may be used for developing food supplements or biofunctional foods for the prevention of oxidative stress-induced pathological conditions of endothelium. Keywords:Rosa canina; Rosa sempervivens; Pyrocantha coccinea; polyphenols; antioxidants; endothelial cells; glutathione This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Share & Cite This Article MDPI and ACS Style Kerasioti, E.; Apostolou, A.; Kafantaris, I.; Chronis, K.; Kokka, E.; Dimitriadou, C.; Tzanetou, E.N.; Priftis, A.; Koulocheri, S.D.; Haroutounian, S.A.; Kouretas, D.; Stagos, D. Polyphenolic Composition of Rosa canina, Rosa sempervivens and Pyrocantha coccinea Extracts and Assessment of Their Antioxidant Activity in Human Endothelial Cells. Antioxidants 2019, 8, 92. Show more citation formats Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here. Article Metrics Article metric data becomes available approximately 24 hours after publication online. 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